A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects

A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects

Background and objective: As a partial positive allosteric modulator of the gamma-aminobutyric acid A (GABAA) receptor, dimdazenil was used for the treatment of insomnia with the potential to alleviate associated side effects compared to full agonists. The objective of this trial is to assess the sa...

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Bibliographic Details
Main Authors: Fei Wang, Jingjing He, Yanling Zhou, Lijun Ye, Bei Li, Zhiyuan Ma, Chunyan Chen, Ruoxi Zhang, Zhaocun Lin, Jinshan Tang, Zhiping Jin, Yu Jiang, Nengming Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
insomnia
dimdazenil
GABAA receptor
partial positive allosteric agonist
pharmacokinetics
safety
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1226014/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1226014/full

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