Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

ABSTRACTEarly detection and surgical treatment are essential to achieve a good outcome in gastric cancer (GC). Stage IV and recurrent GC have a poor prognosis. Therefore, new treatments for GC are needed. We investigated the intestinal microbiome of GC patients and attempted to reverse the immunosup...

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Bibliographic Details
Main Authors: Seung Yoon Lee, JooYeon Jhun, Jin Seok Woo, Kun Hee Lee, Sun-Hee Hwang, Jeonghyeon Moon, Goeun Park, Sun Shim Choi, So Jung Kim, Yoon Ju Jung, Kyo Young Song, Mi-La Cho
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
Gastric cancer
PD-L1
IL-10
microbiome
butyrate
avatar model
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2300846

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https://www.tandfonline.com/doi/10.1080/19490976.2023.2300846

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