Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation

Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation

Zinc (Zn) has antioxidant, anti-inflammatory and anti-proliferative actions, with Zn dysregulation associated with coronary ischemia/reperfusion injury and smooth muscle cell dysfunction. As the majority of studies concerning Zn have been conducted under non-physiological hyperoxic conditions, we co...

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Bibliographic Details
Main Authors: Fan Yang, Matthew J. Smith, Alexander Griffiths, Alexander Morrell, Sarah J. Chapple, Richard C.M. Siow, Theodora Stewart, Wolfgang Maret, Giovanni E. Mann
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Redox Biology
Subjects:
Coronary artery smooth muscle cells
Metals
Metallomics
Metallothionein
Zinc
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001787

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723001787

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