CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment

CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment

Abstract Background Early dissemination to distant organs accounts for the dismal prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Chronic, dysregulated, persistent and unresolved inflammation provides a preferred tumor microenvironment (TME) for tumorigenesis, development, and me...

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Bibliographic Details
Main Authors: Jinxin Tao, Yani Gu, Zeyu Zhang, Guihu Weng, Yueze Liu, Jie Ren, Yanan Shi, Jiangdong Qiu, Yuanyang Wang, Dan Su, Ruobing Wang, Yifan Fu, Tao Liu, Liyuan Ye, Wenhao Luo, Hao Chen, Gang Yang, Zhe Cao, Hua Huang, Jianchun Xiao, Bo Ren, Lei You, Taiping Zhang, Yupei Zhao
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer
Metastasis
Inflammatory reprogramming
Cancer-associated fibroblasts
Organoids
CALB2
Online Access:https://doi.org/10.1186/s13046-024-03201-w

Internet

https://doi.org/10.1186/s13046-024-03201-w

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