A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating, motor neuron degenerative disease without any cure. About 95% of the ALS patients feature abnormalities in the RNA/DNA-binding protein, TDP-43, involving its nucleo-cytoplasmic mislocalization in spinal motor neurons. How TDP-43 pathology trigger...

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Bibliographic Details
Main Authors: Joy Mitra, Muralidhar L Hegde
Format: Article
Language:English
Published: SAGE Publishing 2019-10-01
Series:Journal of Experimental Neuroscience
Online Access:https://doi.org/10.1177/1179069519880166