A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating, motor neuron degenerative disease without any cure. About 95% of the ALS patients feature abnormalities in the RNA/DNA-binding protein, TDP-43, involving its nucleo-cytoplasmic mislocalization in spinal motor neurons. How TDP-43 pathology trigger...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-10-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069519880166 |