Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results in significant pharmacokinetic and pharmacodynamic...

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Detalles Bibliográficos
Autores principales: F. Donelson Smith, Robert H. Pierce, Thomas Thisted, Edward H. van der Horst
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2023-08-01
Colección:Antibodies
Materias:
pH selective antibodies
Warburg effect
cancer immunotherapy
immune checkpoint inhibitors
Acceso en línea:https://www.mdpi.com/2073-4468/12/3/55

Internet

https://www.mdpi.com/2073-4468/12/3/55

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