Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results in significant pharmacokinetic and pharmacodynamic...

Full description

Bibliographic Details
Main Authors: F. Donelson Smith, Robert H. Pierce, Thomas Thisted, Edward H. van der Horst
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Antibodies
Subjects:
pH selective antibodies
Warburg effect
cancer immunotherapy
immune checkpoint inhibitors
Online Access:https://www.mdpi.com/2073-4468/12/3/55

Internet

https://www.mdpi.com/2073-4468/12/3/55

Similar Items