Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions
The pedunculopontine nucleus (PPN) is composed of a morphologically and neurochemically heterogeneous population of neurons, which is severely affected by Parkinson’s disease (PD). However, the role of each subtype of neurons within the PPN in the pathophysiology of PD has not been completely elucid...
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01034/full |
| _version_ | 1819073488771612672 |
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| author | Xuenan Wang Xiwen Geng Xiwen Geng Min Li Jinlu Xie Dadian Chen Hongyu Han Xiaoqian Meng Xiaomeng Yao Xiaomeng Yao Haiyan Zhang Yunfeng Gao Hongli Chang Xiao Zhang Yanan Wang Min Wang |
| author_facet | Xuenan Wang Xiwen Geng Xiwen Geng Min Li Jinlu Xie Dadian Chen Hongyu Han Xiaoqian Meng Xiaomeng Yao Xiaomeng Yao Haiyan Zhang Yunfeng Gao Hongli Chang Xiao Zhang Yanan Wang Min Wang |
| author_sort | Xuenan Wang |
| collection | DOAJ |
| description | The pedunculopontine nucleus (PPN) is composed of a morphologically and neurochemically heterogeneous population of neurons, which is severely affected by Parkinson’s disease (PD). However, the role of each subtype of neurons within the PPN in the pathophysiology of PD has not been completely elucidated. In this study, we present the discharge profiles of three classified subtypes of PPN neurons and their alterations after 6-hydroxydopamine (6-OHDA) lesion. Following 6-OHDA lesion, the spike timing of the Type II (GABAergic) and Type III (glutamatergic) neurons had phase-lock with the oscillations in the delta and beta band frequency range in the PPN, respectively. Morphological evidence has shown distinct alteration in three kinds of neurons after 6-OHDA lesion. These findings revealed that the changes in the firing characteristics of neurons in PPN in hemi-parkinsonism rats are closely associated with damaged neuronal morphology, which would make contributions to the divergence of dysfunctions in Parkinsonism. |
| first_indexed | 2024-12-21T17:54:25Z |
| format | Article |
| id | doaj.art-0e09ff5d0b5242b18a579680e69026f6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-21T17:54:25Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0e09ff5d0b5242b18a579680e69026f62022-12-21T18:55:15ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-09-011310.3389/fnins.2019.01034463347Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine LesionsXuenan Wang0Xiwen Geng1Xiwen Geng2Min Li3Jinlu Xie4Dadian Chen5Hongyu Han6Xiaoqian Meng7Xiaomeng Yao8Xiaomeng Yao9Haiyan Zhang10Yunfeng Gao11Hongli Chang12Xiao Zhang13Yanan Wang14Min Wang15Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaAdvanced Material Genome Innovation Team, Advanced Materials Institute, Shandong Academy of Sciences, Qilu University of Technology, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaDepartment of Physiology, School of Medical Huzhou University, Huzhou Central Hospital, Huzhou, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaSchool of Nursing, Qilu Institute of Technology, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaKey Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan, ChinaThe pedunculopontine nucleus (PPN) is composed of a morphologically and neurochemically heterogeneous population of neurons, which is severely affected by Parkinson’s disease (PD). However, the role of each subtype of neurons within the PPN in the pathophysiology of PD has not been completely elucidated. In this study, we present the discharge profiles of three classified subtypes of PPN neurons and their alterations after 6-hydroxydopamine (6-OHDA) lesion. Following 6-OHDA lesion, the spike timing of the Type II (GABAergic) and Type III (glutamatergic) neurons had phase-lock with the oscillations in the delta and beta band frequency range in the PPN, respectively. Morphological evidence has shown distinct alteration in three kinds of neurons after 6-OHDA lesion. These findings revealed that the changes in the firing characteristics of neurons in PPN in hemi-parkinsonism rats are closely associated with damaged neuronal morphology, which would make contributions to the divergence of dysfunctions in Parkinsonism.https://www.frontiersin.org/article/10.3389/fnins.2019.01034/fullpedunculopontine nucleusParkinson’s diseasefiring patternsynchronizationmorphology |
| spellingShingle | Xuenan Wang Xiwen Geng Xiwen Geng Min Li Jinlu Xie Dadian Chen Hongyu Han Xiaoqian Meng Xiaomeng Yao Xiaomeng Yao Haiyan Zhang Yunfeng Gao Hongli Chang Xiao Zhang Yanan Wang Min Wang Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions Frontiers in Neuroscience pedunculopontine nucleus Parkinson’s disease firing pattern synchronization morphology |
| title | Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions |
| title_full | Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions |
| title_fullStr | Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions |
| title_full_unstemmed | Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions |
| title_short | Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions |
| title_sort | electrophysiological and neurochemical considerations of distinct neuronal populations in the rat pedunculopontine nucleus and their responsiveness following 6 hydroxydopamine lesions |
| topic | pedunculopontine nucleus Parkinson’s disease firing pattern synchronization morphology |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.01034/full |
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