Sclerostin, Osteocytes, and Wnt Signaling in Pediatric Renal Osteodystrophy

Sclerostin, Osteocytes, and Wnt Signaling in Pediatric Renal Osteodystrophy

The pathophysiology of chronic kidney disease-mineral and bone disorder (CKD-MBD) is not well understood. Specific factors secreted by osteocytes are elevated in the serum of adults and pediatric patients with CKD-MBD, including FGF-23 and sclerostin, a known inhibitor of the Wnt signaling pathway....

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Bibliographic Details
Main Authors: Marciana Laster, Renata C. Pereira, Kathleen Noche, Barbara Gales, Isidro B. Salusky, Lauren V. Albrecht
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Nutrients
Subjects:
Wnt signaling
CKD-MBD
children
sclerostin
bone biopsy
immunohistochemistry
Online Access:https://www.mdpi.com/2072-6643/15/19/4127

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https://www.mdpi.com/2072-6643/15/19/4127

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