Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs

Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs

Abstract Background Exosomes derived from dental pulp stem cells (DPSCs) can be used as biomimetic tools to induce odontogenic differentiation of stem cells, but the regulatory mechanisms and functions of exosome-encapsulated microRNAs are still unknown. The present study aimed to clarify the role o...

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Bibliographic Details
Main Authors: Xiaoli Hu, Yingqun Zhong, Yuanyuan Kong, Yanan Chen, Junming Feng, Jianmao Zheng
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
TGFβ pathway
MicroRNAs
Odontogenesis
DPSCs
Online Access:http://link.springer.com/article/10.1186/s13287-019-1278-x

Internet

http://link.springer.com/article/10.1186/s13287-019-1278-x

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