A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?

A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?

Following influenza infection, rs2248374-G ERAP2 expressing cells may transcribe an alternative spliced isoform: ERAP2/Iso3. This variant, unlike ERAP2-wt, is unable to trim peptides to be loaded on MHC class I molecules, but it can still dimerize with both ERAP2-wt and ERAP1-wt, thus contributing t...

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Bibliographic Details
Main Authors: Irma Saulle, Claudia Vanetti, Sara Goglia, Chiara Vicentini, Enrico Tombetti, Micaela Garziano, Mario Clerici, Mara Biasin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
ERAP2
ERAP2/Iso3
microbial infections
alternative splicing
SARS-CoV-2
host cell response
Online Access:https://www.mdpi.com/2073-4409/9/9/1951

Internet

https://www.mdpi.com/2073-4409/9/9/1951

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