Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties

Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties

1.AbstractInterest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g. the European Union´s Cosmetic Directive and REAC...

Full description

Bibliographic Details
Main Authors: Monika Batke, Martin Gütlein, Falko Partosch, Ursula Gundert-Remy, Christoph Helma, Stefan Kramer, Andreas Maunz, Madeleine Seeland, Annette Bitsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Pharmacology
Subjects:
QSAR
read across
Non-animal methods
Predictive Clustering Tree (PCT) method
toxicological and structural similarity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00321/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00321/full

Similar Items