<italic toggle="yes">Bordetella</italic> Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells

<italic toggle="yes">Bordetella</italic> Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells

ABSTRACT Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that binds myeloid phagocytes through complement receptor...

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Bibliographic Details
Main Authors: Jawid Nazir Ahmad, Jana Holubova, Oldrich Benada, Olga Kofronova, Ludek Stehlik, Martina Vasakova, Peter Sebo
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
Bordetella
adenylate cyclase toxin
cyclic AMP
dedifferentiation
macrophage
Online Access:https://journals.asm.org/doi/10.1128/mBio.01743-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01743-19

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