Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl<sub>4</sub> Treated Rats

Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl<sub>4</sub> Treated Rats

MicroRNAs (miRNAs) are short, non-coding RNA species that are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of non-alcoholic fatty liver disease. Here, we investigated the phosphodiesterase 5 (PDE5) inhibitor induced effects on hepatic an...

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Bibliographic Details
Main Authors: Andre Broermann, Ramona Schmid, Ogsen Gabrielyan, Marlene Sakowski, Claudia Eisele, Sascha Keller, Michael Wolff, Patrick Baum, Birgit Stierstorfer, Jochen Huber, Bernhard K. Krämer, Berthold Hocher, Ruediger Streicher, Denis Delić
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
liver fibrosis
CCl<sub>4</sub>
PDE 5 inhibitor
gene expression
microRNAs
exosomes
Online Access:https://www.mdpi.com/1422-0067/22/1/382

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https://www.mdpi.com/1422-0067/22/1/382

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