Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl<sub>4</sub> Treated Rats

Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl<sub>4</sub> Treated Rats

MicroRNAs (miRNAs) are short, non-coding RNA species that are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of non-alcoholic fatty liver disease. Here, we investigated the phosphodiesterase 5 (PDE5) inhibitor induced effects on hepatic an...

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Bibliographic Details
Main Authors:	Andre Broermann, Ramona Schmid, Ogsen Gabrielyan, Marlene Sakowski, Claudia Eisele, Sascha Keller, Michael Wolff, Patrick Baum, Birgit Stierstorfer, Jochen Huber, Bernhard K. Krämer, Berthold Hocher, Ruediger Streicher, Denis Delić
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	International Journal of Molecular Sciences
Subjects:	liver fibrosis CCl<sub>4</sub> PDE 5 inhibitor gene expression microRNAs exosomes
Online Access:	https://www.mdpi.com/1422-0067/22/1/382

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