PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2) complex, to enforce transcriptional repression and...

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Bibliographic Details
Main Authors: Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Virology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224003730

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http://www.sciencedirect.com/science/article/pii/S2589004224003730

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