Amlodipine rescues advanced iron overload cardiomyopathy in hemojuvelin knockout murine model: Clinical implications

Amlodipine rescues advanced iron overload cardiomyopathy in hemojuvelin knockout murine model: Clinical implications

BackgroundIron overload cardiomyopathy (IOC) is a major co-morbidity of genetic hemochromatosis and secondary iron overload with limited therapeutic options. We aim to investigate mechanisms of rescue action of amlodipine in the murine model of iron overload, characterize changes in human cardiac ti...

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Bibliographic Details
Main Authors: Pavel Zhabyeyev, Chandu Sadasivan, Saumya Shah, Faqi Wang, Gavin Y. Oudit
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
iron overload
cardiomyopathy
hemochromatosis
calcium channel blockers
hemojuvelin
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1129349/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1129349/full

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