Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated.

Bibliographic Details
Main Authors: Brandon L. Pierce, Lin Tong, Maria Argos, Kathryn Demanelis, Farzana Jasmine, Muhammad Rakibuz-Zaman, Golam Sarwar, Md. Tariqul Islam, Hasan Shahriar, Tariqul Islam, Mahfuzar Rahman, Md. Yunus, Muhammad G. Kibriya, Lin S. Chen, Habibul Ahsan
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03209-9

Internet

https://doi.org/10.1038/s41467-018-03209-9

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