Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms
Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated.
Bibliographic Details
| Main Authors: |
Brandon L. Pierce,
Lin Tong,
Maria Argos,
Kathryn Demanelis,
Farzana Jasmine,
Muhammad Rakibuz-Zaman,
Golam Sarwar,
Md. Tariqul Islam,
Hasan Shahriar,
Tariqul Islam,
Mahfuzar Rahman,
Md. Yunus,
Muhammad G. Kibriya,
Lin S. Chen,
Habibul Ahsan |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03209-9
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