Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms
Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03209-9 |
| _version_ | 1818427229680435200 |
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| author | Brandon L. Pierce Lin Tong Maria Argos Kathryn Demanelis Farzana Jasmine Muhammad Rakibuz-Zaman Golam Sarwar Md. Tariqul Islam Hasan Shahriar Tariqul Islam Mahfuzar Rahman Md. Yunus Muhammad G. Kibriya Lin S. Chen Habibul Ahsan |
| author_facet | Brandon L. Pierce Lin Tong Maria Argos Kathryn Demanelis Farzana Jasmine Muhammad Rakibuz-Zaman Golam Sarwar Md. Tariqul Islam Hasan Shahriar Tariqul Islam Mahfuzar Rahman Md. Yunus Muhammad G. Kibriya Lin S. Chen Habibul Ahsan |
| author_sort | Brandon L. Pierce |
| collection | DOAJ |
| description | Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated. |
| first_indexed | 2024-12-14T14:42:25Z |
| format | Article |
| id | doaj.art-0e237f531ba64865aebc696a3861462b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:42:25Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0e237f531ba64865aebc696a3861462b2022-12-21T22:57:23ZengNature PortfolioNature Communications2041-17232018-02-019111210.1038/s41467-018-03209-9Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanismsBrandon L. Pierce0Lin Tong1Maria Argos2Kathryn Demanelis3Farzana Jasmine4Muhammad Rakibuz-Zaman5Golam Sarwar6Md. Tariqul Islam7Hasan Shahriar8Tariqul Islam9Mahfuzar Rahman10Md. Yunus11Muhammad G. Kibriya12Lin S. Chen13Habibul Ahsan14Department of Public Health Sciences, The University of ChicagoDepartment of Public Health Sciences, The University of ChicagoDivision of Epidemiology and Biostatistics, University of Illinois at ChicagoDepartment of Public Health Sciences, The University of ChicagoDepartment of Public Health Sciences, The University of ChicagoUChicago Research BangladeshUChicago Research BangladeshUChicago Research BangladeshUChicago Research BangladeshUChicago Research BangladeshUChicago Research BangladeshInternational Centre for Diarrhoeal Disease Research BangladeshDepartment of Public Health Sciences, The University of ChicagoDepartment of Public Health Sciences, The University of ChicagoDepartment of Public Health Sciences, The University of ChicagoMost expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated.https://doi.org/10.1038/s41467-018-03209-9 |
| spellingShingle | Brandon L. Pierce Lin Tong Maria Argos Kathryn Demanelis Farzana Jasmine Muhammad Rakibuz-Zaman Golam Sarwar Md. Tariqul Islam Hasan Shahriar Tariqul Islam Mahfuzar Rahman Md. Yunus Muhammad G. Kibriya Lin S. Chen Habibul Ahsan Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms Nature Communications |
| title | Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_full | Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_fullStr | Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_full_unstemmed | Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_short | Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_sort | co occurring expression and methylation qtls allow detection of common causal variants and shared biological mechanisms |
| url | https://doi.org/10.1038/s41467-018-03209-9 |
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