Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells

Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells

Abstract Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve genomic stability. However, the molecular mechanisms underlying telomere attrition-induced genome instability remain to be understood. We systematically analyzed the expression of retrotransposons and perfor...

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Bibliographic Details
Main Authors: Nannan Zhao, Guoxing Yin, Chun Liu, Weiyu Zhang, Yang Shen, Dan Wang, Zhenzhen Lin, Jiao Yang, Jian Mao, Renpeng Guo, Yongwang Zhang, Feng Wang, Zhe Liu, Xinyi Lu, Lin Liu
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00538-y

Internet

https://doi.org/10.1038/s41421-023-00538-y

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