Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of atomic motions in MarRs remains unexplored thus li...

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Bibliographic Details
Main Authors: Daiana A Capdevila, Fidel Huerta, Katherine A Edmonds, My Tra Le, Hongwei Wu, David P Giedroc
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
Conformational Entropy
Allosteric Activation
MarR family repressors
Streptococcus pneumoniae
adhesin competence regulator
zinc homeostasis
Online Access:https://elifesciences.org/articles/37268

Internet

https://elifesciences.org/articles/37268

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