TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes

TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes

IntroductionChronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibiting PD1/PD-L1 signaling results in autoimmune diabet...

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Bibliographic Details
Main Authors: Prerak Trivedi, Gaurang Jhala, David J. De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W. Kay, Helen E. Thomas, Balasubramanian Krishnamurthy
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
TIGIT
CD8+ T cell
immune checkpoint
NOD mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1370907/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1370907/full

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