CNTN-1 Enhances Chemoresistance in Human Lung Adenocarcinoma Through Induction of Epithelial-Mesenchymal Transition by Targeting the PI3K/Akt Pathway

CNTN-1 Enhances Chemoresistance in Human Lung Adenocarcinoma Through Induction of Epithelial-Mesenchymal Transition by Targeting the PI3K/Akt Pathway

Background/Aims: Chemoresistance has been a major obstacle to the effective treatment of lung cancer. Previously, we found that contactin-1 (CNTN-1) is related to cisplatin resistance in lung adenocarcinoma. Here, we aimed to investigate the underlying mechanism behind the role of CNTN-1 in cisplati...

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Bibliographic Details
Main Authors: Ruijie Zhang, Shenghua Sun, Fuyun Ji, Chun Liu, Hua Lin, Lihua Xie, Honghui Yang, Wenxiang Tang, Yan Zhou, Jianping Xu, Pei Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
PI3K/Akt
Chemoresistance
NSCLC
CNTN-1
EMT
Online Access:http://www.karger.com/Article/FullText/480473

Internet

http://www.karger.com/Article/FullText/480473

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