Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses

Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses

Influenza hemagglutinin (HA) is considered a major protective antigen of seasonal influenza vaccine but antigenic drift of HA necessitates annual immunizations using new circulating HA versions. Low variation found within conserved non-HA influenza virus (INFV) antigens may maintain protection with...

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Bibliographic Details
Main Authors: Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanné Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
modified Vaccinia virus Ankara (MVA)
influenza A
nucleoprotein
matrix protein 1
matrix protein 2
hemagglutinin
Online Access:https://www.mdpi.com/1999-4915/13/9/1708

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https://www.mdpi.com/1999-4915/13/9/1708

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