VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury

VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury

Background: As a novel non-apoptotic cell death, ferroptosis has been reported to play a crucial role in acute kidney injury (AKI), especially cisplatin-induced AKI. Valproic acid (VPA), an inhibitor of histone deacetylase (HDAC) 1 and 2, is used as an antiepileptic drug. Consistent with our data, a...

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Bibliographic Details
Main Authors: Yan Li, Ke Li, Weihao Zhao, Haodong Wang, Xiaodong Xue, Xianghui Chen, Wantao Li, Peihao Xu, Kexin Wang, Pengfei Liu, Xuefei Tian, Rongguo Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
HDAC inhibitor
cisplatin
acute kidney injury
VPA
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1147772/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1147772/full

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