Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in <italic toggle="yes">Mycobacterium tuberculosis</italic>

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in <italic toggle="yes">Mycobacterium tuberculosis</italic>

ABSTRACT Indole propionic acid (IPA), produced by the gut microbiota, is active against Mycobacterium tuberculosis in vitro and in vivo. However, its mechanism of action is unknown. IPA is the deamination product of tryptophan (Trp) and thus a close structural analog of this essential aromatic amino...

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Bibliographic Details
Main Authors: Dereje Abate Negatu, Yoshiyuki Yamada, Yu Xi, Mei Lin Go, Matthew Zimmerman, Uday Ganapathy, Véronique Dartois, Martin Gengenbacher, Thomas Dick
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
NTM
TrpE
allosteric inhibitor
antibiotic
tryptophan mimic
Online Access:https://journals.asm.org/doi/10.1128/mBio.02781-18

Internet

https://journals.asm.org/doi/10.1128/mBio.02781-18

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