Expression of proinflammatory cytokines and proinsulin by bone marrow-derived cells for fracture healing in long-term diabetic mice

Expression of proinflammatory cytokines and proinsulin by bone marrow-derived cells for fracture healing in long-term diabetic mice

Abstract Background Diabetes mellitus (DM) causes bone dysfunction due to poor bone quality, leading to severe deterioration in patient of quality of life. The mechanisms of bone metabolism in DM remain unclear, although chemical and/or mechanical factors are known to disrupt the homeostasis of oste...

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Bibliographic Details
Main Authors: Hitomi Fujikawa, Hideto Kojima, Tomoya Terashima, Miwako Katagi, Takafumi Yayama, Kosuke Kumagai, Kanji Mori, Hideki Saito, Shinji Imai
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Long-term hyperglycaemia
Fracture healing
TNF-α
Proinsulin
Bone marrow transplantation
Online Access:https://doi.org/10.1186/s12891-023-06710-5

Internet

https://doi.org/10.1186/s12891-023-06710-5

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