Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear

Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear

The loss of inner ear hair cells causes permanent hearing and balance deficits in humans and other mammals, but non-mammals recover after supporting cells (SCs) divide and replace hair cells. The proliferative capacity of mammalian SCs declines as exceptionally thick circumferential F-actin bands de...

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Bibliographic Details
Main Authors: Mark A. Rudolf, Anna Andreeva, Christina E. Kim, Anthony C.-J. DeNovio, Antoan N. Koshar, Wendy Baker, Alexander X. Cartagena-Rivera, Jeffrey T. Corwin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hair cell
utricle
regeneration
F-actin (filamentous actin)
epithelial mechanics
alpha actinin 4
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.859882/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.859882/full

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