Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

Mesenchymal stem cells (MSCs) experience substantial viability issues in the stroke infarct region, limiting their therapeutic efficacy and clinical translation. High levels of deadly reactive oxygen radicals (ROS) and proinflammatory cytokines (PC) in the infarct milieu kill transplanted MSCs, wher...

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Bibliographic Details
Main Authors: Jianpei Xu, Yinzhe Sun, Yang You, Yuwen Zhang, Dan Huang, Songlei Zhou, Yipu Liu, Shiqiang Tong, Fenfen Ma, Qingxiang Song, Chengxiang Dai, Suke Li, Jigang Lei, Zhihua Wang, Xiaoling Gao, Jun Chen
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ischemic stroke
Mesenchymal stem cell
Cell engineering
Hormesis effect
Bioorthogonal chemistry
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352300432X

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http://www.sciencedirect.com/science/article/pii/S221138352300432X

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