Microsatellite Status Detection in Gastrointestinal Cancers: PCR/NGS Is Mandatory in Negative/Patchy MMR Immunohistochemistry

Microsatellite Status Detection in Gastrointestinal Cancers: PCR/NGS Is Mandatory in Negative/Patchy MMR Immunohistochemistry

Background: Microsatellite instability (MSI) is a predictive biomarker for immune checkpoint inhibitors. The main goal was to investigate the discordance between IHC and PCR/NGS for MSI testing in gastrointestinal cancers. Methods: Two series were analyzed through IHC for mismatch-repair-system prot...

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Bibliographic Details
Main Authors: Federica Zito Marino, Martina Amato, Andrea Ronchi, Iacopo Panarese, Franca Ferraraccio, Ferdinando De Vita, Giuseppe Tirino, Erika Martinelli, Teresa Troiani, Gaetano Facchini, Felice Pirozzi, Michele Perrotta, Pasquale Incoronato, Raffaele Addeo, Francesco Selvaggi, Francesco Saverio Lucido, Michele Caraglia, Giovanni Savarese, Roberto Sirica, Marika Casillo, Eva Lieto, Annamaria Auricchio, Francesca Cardella, Ludovico Docimo, Gennaro Galizia, Renato Franco
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
microsatellite instability
gastrointestinal cancers
mismatch-repair-system-protein deficient
mismatch-repair-system-protein patchy
PCR
Online Access:https://www.mdpi.com/2072-6694/14/9/2204

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https://www.mdpi.com/2072-6694/14/9/2204

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