Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage

Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage

Background: Neuroprotection studies are generally unable to demonstrate efficacy in humans. Our specific hypothesis is that multiple pathophysiologic pathways, of variable importance, contribute to ischemic brain damage. As a corollary to this, we discuss the broad hypothesis that a multifaceted app...

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Bibliographic Details
Main Authors: William A. Kofke, Yue Ren, John G. Augoustides, Hongzhe Li, Katherine Nathanson, Robert Siman, Qing Cheng Meng, Weiming Bu, Sukanya Yandrawatthana, Guy Kositratna, Cecilia Kim, Joseph E. Bavaria
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neurology
Subjects:
neuroprotection
functional genomics
cerebral ischemia
cardiac surgery
cardiopulmonary bypass
biomarkers
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00497/full

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https://www.frontiersin.org/article/10.3389/fneur.2018.00497/full

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