Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Abstract Background Alzheimer’s disease (AD) is responsible for 60–70% of all cases of dementia. On the other hand, the tap water consumed by hundreds of millions of people has been fluoridated to prevent tooth decay. However, little is known about the influence of fluoride on the expression of APP...

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Bibliographic Details
Main Authors: Kun Cao, Jie Xiang, Yang-Ting Dong, Yi Xu, Yi Li, Hui Song, Xiao-Xiao Zeng, Long-Yan Ran, Wei Hong, Zhi-Zhong Guan
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
APP/PS1 double-transgenic mice
Fluorosis
Learning and memory
Neuropathology
Online Access:http://link.springer.com/article/10.1186/s13195-019-0490-3

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http://link.springer.com/article/10.1186/s13195-019-0490-3

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