Electrostatic complementarity at the interface drives transient protein-protein interactions

Abstract Understanding the mechanisms driving bio-molecules binding and determining the resulting complexes’ stability is fundamental for the prediction of binding regions, which is the starting point for drug-ability and design. Characteristics like the preferentially hydrophobic composition of the...

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Bibliographic Details
Main Authors: Greta Grassmann, Lorenzo Di Rienzo, Giorgio Gosti, Marco Leonetti, Giancarlo Ruocco, Mattia Miotto, Edoardo Milanetti
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-37130-z