A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia

A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia

Introduction: Long axial length (AL) is a risk factor for myopia. Although family studies indicate that AL has an important genetic component with heritability estimates up to 0.94, there have been few reports of AL-associated loci.Methods: Here, we conducted a multiethnic genome-wide association st...

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Bibliographic Details
Main Authors: Chen Jiang, Ronald B. Melles, Jie Yin, Qiao Fan, Xiaobo Guo, Ching-Yu Cheng, Mingguang He, David A. Mackey, Jeremy A. Guggenheim, Caroline Klaver, Consortium for Refractive Error and Myopia (CREAM), K. Saidas Nair, Eric Jorgenson, Hélène Choquet
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Genetics
Subjects:
GWAS
genetics
single nucleotide polymorphisms (SNPs)
axial length
eye biometry
refractive errors
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1113058/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1113058/full

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