Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-GDNF (β-GDNF), which has a 26 amino acid deletion in the pro-region. Thus far, studies have focused solely on the α-GDNF...

Full description

Bibliographic Details
Main Authors: Anna-Maija Penttinen, Ilmari Parkkinen, Merja H. Voutilainen, Maryna Koskela, Susanne Bäck, Anna Their, Christopher T. Richie, Andrii Domanskyi, Brandon K. Harvey, Raimo K. Tuominen, Liina Nevalaita, Mart Saarma, Mikko Airavaara
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neurology
Subjects:
neurotrophic factors
neurodegeneration
GDNF
splice variant
alternative splicing
tyrosine hydroxylase
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00457/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00457/full

Similar Items