Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells

Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells

Abstract Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) remodeling and fibroblast activity, play pivotal rol...

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Bibliographic Details
Main Authors: Guangsheng Zhu, Yanan Wang, Yingjie Wang, Hua Huang, Boshi Li, Peijie Chen, Chen Chen, Hongbing Zhang, Yongwen Li, Hongyu Liu, Jun Chen
Format: Article
Language:English
Published: Nature Publishing Group 2024-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06873-6

Internet

https://doi.org/10.1038/s41419-024-06873-6

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