A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

Polymyxins are often the last therapeutic option for multidrug-resistant (MDR) bacteria, but have suboptimal safety and efficacy. Here the authors report the discovery and development of a synthetic lipopeptide with an improved safety and efficacy against top-priority MDR Gram-negative pathogens.

Bibliographic Details
Main Authors: Kade D. Roberts, Yan Zhu, Mohammad A. K. Azad, Mei-Ling Han, Jiping Wang, Lynn Wang, Heidi H. Yu, Andrew S. Horne, Jo-Anne Pinson, David Rudd, Nicolas H. Voelcker, Nitin A. Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J. Hecker, Philip E. Thompson, Roger L. Nation, Michael N. Dudley, David C. Griffith, Tony Velkov, Jian Li
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29234-3

Internet

https://doi.org/10.1038/s41467-022-29234-3

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