A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death

Recent findings suggest that dopamine oxidation contributes to the development of Parkinson's disease (PD); however, the mechanistic details remain elusive. Here, we compare 6-hydroxydopamine (6-OHDA), a product of dopamine oxidation that commonly induces dopaminergic neurodegeneration in labor...

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Bibliographic Details
Main Authors: Ali Farzam, Karan Chohan, Miroslava Strmiskova, Sarah J. Hewitt, David S. Park, John P. Pezacki, Dennis Özcelik
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719308973