Total Synthesis of Hematoporphyrin and Protoporphyrin; a Conceptually New Approach

Total Synthesis of Hematoporphyrin and Protoporphyrin; a Conceptually New Approach

The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2. Coupling of the two fragments...

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Bibliographic Details
Main Authors: Pierre Martin, Markus Müller, Dietmar Flubacher, Andreas Boudier, Dirk Spielvogel
Format: Article
Language:deu
Published: Swiss Chemical Society 2013-04-01
Series:CHIMIA
Subjects:
Development & scale-up
Novel porphyrin cyclization method
Process research
Protoporphyrin ix
Total synthesis
Online Access:https://www.chimia.ch/chimia/article/view/5365

Internet

https://www.chimia.ch/chimia/article/view/5365

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