In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG+ve B Cells

In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG+ve B Cells

B cells are critical for promoting autoimmunity and the success of B cell depletion therapy in rheumatoid arthritis (RA) confirms their importance in driving chronic inflammation. Whilst disease specific autoantibodies are useful diagnostically, our understanding of the pathogenic B cell repertoire...

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Bibliographic Details
Main Authors: Graeme J. M. Cowan, Katherine Miles, Lorenzo Capitani, Sophie S. B. Giguere, Hanna Johnsson, Carl Goodyear, Iain B. McInnes, Steffen Breusch, David Gray, Mohini Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
B cells
BCR
autoimmunity
TNF
rheumatoid arthritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00395/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00395/full

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