Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1

Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1

Diabetic kidney disease is a major cause of chronic kidney condition and the most common complication of diabetes. The cellular senescence participates in the process of diabetic kidney disease, but the specific mechanism is not yet clear. Cell cycle-related protein E2F transcription factor 1 (E2F1)...

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Bibliographic Details
Main Authors: Dan Liang, Zhiyang Li, Zhaowei Feng, Zhiping Yuan, Yunli Dai, Xin Wu, Fan Zhang, Yuanyuan Wang, Yuxia Zhou, Lingling Liu, Mingjun Shi, Ying Xiao, Bing Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
metformin
diabetic kidney disease
DNA damage
renal tubular epithelial cells
fibrosis
E2F1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.926211/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.926211/full

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