Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases

Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The adenylation (A) domain is a key catalytic domain t...

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Bibliographic Details
Main Authors: Mengli Zhang, Zijing Peng, Zhenkuai Huang, Jiaqi Fang, Xinhai Li, Xiaoting Qiu
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Marine Drugs
Subjects:
adenylation domain in nonribosomal peptide synthetase
substrate-specificity codes of the adenylation domain
interrupted adenylation domain with methylase activity
nonribosomal peptide synthetase engineering targeting the adenylation domain
Online Access:https://www.mdpi.com/1660-3397/22/8/349

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https://www.mdpi.com/1660-3397/22/8/349

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