Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.

Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.

Cytochrome P450 (P450) is a super-family of drug metabolizing enzymes. P450 enzymes have dual function; they can metabolize drugs to pharmacologically inactive metabolites facilitating their excretion or biotransform them to pharmacologically active metabolites which may have longer half-life than t...

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Bibliographic Details
Main Authors: Varsha Agarwal, Reddy P Kommaddi, Khader Valli, Daniel Ryder, Thomas M Hyde, Joel E Kleinman, Henry W Strobel, Vijayalakshmi Ravindranath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2408964?pdf=render

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http://europepmc.org/articles/PMC2408964?pdf=render

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