Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting donor-derived human leukocyte antigen (HLA) is a promising strategy to promote transplant tolerance. Here, we describe an anti-HLA-A2 CAR (A2-CAR) generated by grafting the complementarity-determining...

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Bibliographic Details
Main Authors: Yannick D. Muller, Leonardo M. R. Ferreira, Emilie Ronin, Patrick Ho, Vinh Nguyen, Gaetano Faleo, Yu Zhou, Karim Lee, Kevin K. Leung, Nikolaos Skartsis, Anupurna M. Kaul, Arend Mulder, Frans H. J. Claas, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
regulatory T cells
genome editing
transplantation
humanized mouse model
immune tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.686439/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.686439/full

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