MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription

MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription

Reactive oxygen species (ROS) promotes vascular injury and neointima formation in part by stimulating proliferation of vascular smooth muscle cells (VSMC). The underlying transcriptional mechanism, however, is not completely understood. Here we report that VSMC-specific deletion of MKL1 in mice supp...

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Bibliographic Details
Main Authors: Teng Wu, Nan Li, Qiumei Zhang, Ruiqi Liu, Hongwei Zhao, Zhiwen Fan, Lili Zhuo, Yuyu Yang, Yong Xu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
Transcriptional regulation
Post-translational modification
Vascular injury
Vascular smooth muscle cell
Proliferation
Phenotypic modulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003585

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http://www.sciencedirect.com/science/article/pii/S2213231722003585

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