Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

A microflow system consisting of micromixers and microtube reactors provides an effective method for the introduction of two electrophiles onto dibromobiaryls. Selective monolithiation of dibromobiaryls, such as 2,2′-dibromobiphenyl, 4,4′-dibromobiphenyl, 2,7-dibromo-9,9-dioctylfluorene, 2,2′-dibrom...

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Bibliographic Details
Main Authors: Aiichiro Nagaki, Naofumi Takabayashi, Yutaka Tomida, Jun-ichi Yoshida
Format: Article
Language:English
Published: Beilstein-Institut 2009-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
dibromobiaryls
fast mixing
integrated microflow system
selective lithiation
unsymmetrically substituted biaryls
Online Access:https://doi.org/10.3762/bjoc.5.16

Internet

https://doi.org/10.3762/bjoc.5.16

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