Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. We studied whether a persistent cognitive/emotional dysregulation in mice withdrawn from cocaine holds a neurobiological correlate within the hippocampus, a limbic region with a k...

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Bibliographic Details
Main Authors: David Ladrón de Guevara-Miranda, Carmelo Millón, Cristina Rosell-Valle, Mercedes Pérez-Fernández, Michele Missiroli, Antonia Serrano, Francisco J. Pavón, Fernando Rodríguez de Fonseca, Magdalena Martínez-Losa, Manuel Álvarez-Dolado, Luis J. Santín, Estela Castilla-Ortega
Format: Article
Language:English
Published: The Company of Biologists 2017-03-01
Series:Disease Models & Mechanisms
Subjects:
Anxiety
c-Fos
Parvalbumin
Neuropeptide Y
Cell proliferation
Behavior-induced neuroplasticity
Online Access:http://dmm.biologists.org/content/10/3/323

Internet

http://dmm.biologists.org/content/10/3/323

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