Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier

Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier

Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the Toll-like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory diseases. Studies showed a significant correlation between TLRs and inflammatory responses in ulcerative colitis (UC). Theref...

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Bibliographic Details
Main Authors: Bo Yan, Xiangjie Li, Linxiang Zhou, Yuqing Qiao, Jing Wu, Lanlan Zha, Peilu Liu, Shuai Peng, Baixin Wu, Xiaoyun Yu, Lei Shen
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022-10-01
Series:Biomolecules & Biomedicine
Subjects:
IRAK1/4
ulcerative colitis
TLR4/NF-κB
intestinal barrier
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/7348

Internet

https://www.bjbms.org/ojs/index.php/bjbms/article/view/7348

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