Discovery of New Quinoline-Based Diarylamides as Potent B-RAF<sup>V600E</sup>/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity

The emergence of cancer resistance to targeted therapy represents a significant challenge in cancer treatment. Therefore, identifying new anticancer candidates, particularly those addressing oncogenic mutants, is an urgent medical demand. A campaign of structural modifications has been conducted to...

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Bibliographic Details
Main Authors: Hyun Ji Kim, Jung Woo Park, Sangjae Seo, Kwang-Hwi Cho, Mohammed M. Alanazi, Eun-Kyoung Bang, Gyochang Keum, Ashraf K. El-Damasy
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/24/4/3216